Proteostasis是一个什么概念,全称是proteinhomeostasis.

Question

Proteostasis是一个什么概念,全称是protein homeostasis.

Answer 1

Proteostasis = protein homeostasis
[生化] 蛋白质内稳态.
态是指通过调节细胞内蛋白质来维持细胞蛋白组和组织本身健康的过程.同样的,这个过程也是细胞成长发展以及改善细胞老化和保护细胞对抗疾病工作的中心.细胞内稳态不是仅仅涉及单个通路或者进程,而是通过高度互联的网络来维持.这个网络由很多复杂的控制通路组成,尤其是蛋白的合成、折叠、运输、聚集、解集和降解通路.也就是说,蛋白质内稳态网络管理并控制着蛋白质从出生到死亡的生命之路.
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Protein homeostasis or ‘proteostasis’ is the process that regulates proteins within the cell in order to maintain the health of both the cellular proteome and the organism itself.As such,the process is central to cell development,as well as working to ameliorate the rigours of cellular ageing and protecting cells against disease.Proteostasis does not involve just a single pathway or process but is maintained by a highly inter-connected network comprising many complex pathways that control,inter alia,the synthesis,folding,trafficking,aggregation,disaggregation,and degradation of proteins.In other words,the proteostasis network governs and controls the life path of a protein from birth to death.
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