什么是variantallelefraction（VAF）?这个名词的中文是什么?含义是什么?在文献中看到“ThemajorityoftheidentifiedvariantsineachAMLsampleformedavariantclusterwithavariantallelefraction(VAF)of45%–50%,whichco

Question

什么是variant allele fraction（VAF）?
这个名词的中文是什么?含义是什么?在文献中看到“
The majority of the identified variants in
each AML sample formed a variant cluster with a variant allele
fraction (VAF) of 45%–50%,which corresponds to heterozygous
somatic mutations present in nearly all cells in the sample; this
variant cluster marks the founding clone,from which all leukemic
cells descend.”这样的描述,不明白VAF无法往下看啊!

Answer 1

中文是：等位基因变体分数
应该是等位基因中变体占的百分数!