英语翻译Poly-(1,6)-β-D-glucopyranosyl-(1,3)- β-D-glucopyranose (PGG) β-glucan is a soluble yeast-derived polysaccharide that haspreviously been shown to induce hematopoietic progenitor cell (HPC) mobilization.However,the mobilizing mechanism o

Question

英语翻译
Poly-(1,6)-β-D-glucopyranosyl-(1,3)- β-D-glucopyranose (PGG) β-glucan is a soluble yeast-derived polysaccharide that haspreviously been shown to induce hematopoietic progenitor cell (HPC) mobilization.However,the mobilizing mechanism of action remains unknown.Here,we confirmed that PGG β-glucan alone or in combination with granulocyte colony-stimulating factor (G-CSF) mobilizes HPC into the periphery.Optimal mobilizing effects were seen 24–48 hours after PGGβ-glucan doses of 4.8–9.6 mg/kg.Animals treated with G-CSF and PGGβ-glucan showed a collabo-rative effect in HPC mobilization compared with G-CSF treatment alone.Additional studies demonstrated that neither complement 3 nor complement receptor 3 played a role in this effect and that PGGβ-glucan treatment did not induce proinflammatory cytokine secretion.However,bone marrow cells from PGGβ-glucan-treated mice secreted abundant matrix metalloproteinase-9 (MMP-9),and PGGβ-glucan-induced HPC mobilization was abrogated in MMP-9 knockout mice.Moreover,we demonstrated that both hematopoietic and nonhematopoietic cells contributed to MMP-9 secretion upon PGGβ-glucan treatment.In addition,HPCs mobilized by PGGβ-glucan had similar levels of engraftment in host and lineage differentiation capability compared with those mobilized by G-CSF.Thus,PGG -glucan is an agent that enhances HPC mobilization and may improve the outcome of clinical stem cell transplantation.
软件翻译的明显很多地方词不达意，效果好一点。

Answer 1

聚（1,6）-β-D -葡糖基（ 1,3）-β-D-葡萄糖（P G G）β-葡聚糖是一种可溶性酵母源性多糖已被证明具有诱导造血祖细胞（HPC）活化的作用.然而,该活化的作用机制仍然尚未可知.我们证实了PGGβ-葡聚糖单独或联合粒细胞...