英语翻译Overall,thesedatasupportamodelinwhichPLAGL2functionsprimarilytoaffectgliomagenesisviaitsimpactondifferentiationandself-renewal(Figure8).IntheunstimulatedNSC/progenitorcellslackingPLAGL2overexpression,theWntrec

Question

英语翻译
Overall,these data support a model in which PLAGL2 functions primarily to affect gliomagenesis via its impact on differentiation and self-renewal(Figure 8).
In the unstimulated NSC/progenitor cells lacking PLAGL2 overexpression,the Wnt receptor complexes are not bound by ligands,allowing the axin/APC/GSK3βcomplex to phosphorylate β-catenin and target it for rapid degradation.

Answer 1

总的来说,这些数据支持一个模型,其中PLAGL2影响主要职能是通过影响gliomagenesis诱导分化、自强(图8).
在unstimulated缺乏其他祖细胞,Wnt PLAGL2实验受体配合物不受配体,允许axin / APC / GSK3βcomplex phosphorylateβ-catenin和目标,为快速恶化.